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KMID : 1007420110090030194
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Mood and Emotion
2011 Volume.9 No. 3 p.194 ~ p.201
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The Association between Serum Leptin, Active Ghrelin, Adiponectin and Metabolic Syndrome in Patients with Bipolar Disorde
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Kim Eun-Young
Lee Hyun-Jeong
Lee Nam-Young
Yu Han-Young
Kim Yong-Sik
Ahn Yong-Min
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Abstract
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Objectives : We aimed to investigate the association between metabolic syndrome and serum leptin, active ghrelin,and adiponectin levels in patients with bipolar disorder.
Methods : A total of 100 Korean bipolar patients were assessed for the diagnosis of metabolic syndrome and their serum leptin, active ghrelin, and adiponectin levels were measured.
Results : Metabolic syndrome was found in 29% ; 42.5% of men and 20.0% of women. Abnormality of waist circumference was reported most frequently for both sexes (57.5%). Male patients showed significantly higher serum leptin, active ghrelin, adiponectin levels than female. In both sexes, leptin levels were significantly correlated with higher waist circumference and BMI, which were negatively correlated with active ghrelin levels. Male patients with metabolic syndrome showed significantly lower active ghrelin levels than those without, whereas leptin and active ghrelin levels were not different according to the presence of metabolic syndrome in box sexes.
Conclusion : Metabolic syndrome was frequent in patients with bipolar disorder and abnormality of waist circumference was the most frequent subcomponent of metabolic syndrome. Serum active ghrelin levels were lower in male patients with metabolic syndrome.
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KEYWORD
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Bipolar disorder, Metabolic syndrome, Leptin, Ghrelin, Adiponectin
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